The biology and biological systems and mechanisms behind the formation, progression and treatment of cancer.



aka Cell Death. Apoptosis is a process where a cell is degraded in order for it to be ultimately engulfed and recycled. Apoptosis can occur when a cell has become mutated and is on the verge of becoming a cancer. Apoptosis is also the reason why we don't have webbed hands and feet. What basically happens is that the killer t cell communicates with the diseased cell by adhering to it by binding its death ligand to the death receptor on the diseased cell. This causes adapter proteins to attach to the cytosolic side of the receptor. This leads to a signal cascade which involves the recruitment of various other proteins and ultimately results in the death of the cell. Credits: Drew Berry http://features.cgsociety.org/story_custom.php?story_id=3195


Apoptosis in cancer: from pathogenesis to treatment
Apoptosis: A Review of Programmed Cell Death
Apoptosis and non-apoptotic deaths in cancer development and treatment response
Apoptosis in cancer
Cancer: Death Receptors
Introduction to Cancer Biology (Part 2): Loss of Apoptosis
Apoptotic Pathways